Cryptic crossword clue
First beast of burden being loaded close to the centre 8

The most common and most likely answer to this crossword clue is the 8 letter word PROXIMAL

I've seen this crossword clue in The Guardian
P
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O
X
I
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Buddy explains!

The straight part
We know that "close to the centre" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case close to the centre = proximal.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PROXIMAL mean?

PROXIMAL adjective
  1. Closer to the point of attachment or observation.
  2. Facing toward another tooth. The proximal surfaces of a tooth are those that touch or are close to neighboring teeth.
  3. Closer to the speaker.

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