Cryptic crossword clue
  First home or last home? What’s first, not what’s last 4

The most common and most likely answer to this crossword clue is the 4 letter word WOMB

I've seen this crossword clue in Independent
W
O
M
B


Buddy explains!

The straight part
We know that "First home" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case first home = womb.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WOMB mean?

WOMB noun
  1. In female mammals, the organ in which the young are conceived and grow until birth; the uterus.
  2. The abdomen or stomach.
  3. The stomach of a person or creature.
  4. A place where something is made or formed.
  5. Any cavity containing and enveloping anything.
WOMB verb
  1. To enclose in a womb, or as if in a womb; to breed or hold in secret.

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