Cryptic crossword clue
First Lady hates cooking meat loaf 6

The most common and most likely answer to this crossword clue is the 6 letter word HASLET

I've seen this crossword clue in The Guardian
H
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Buddy explains!

The straight part
We know that "meat loaf" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case meat loaf = haslet.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HASLET mean?

HASLET noun
  1. The internal organs of an animal, especially the heart and liver of a pig.
  2. A meatloaf made of these organs.

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