Cryptic crossword clue
First Lady in Pennsylvania, North Dakota, Oregon area 7

The most common and most likely answer to this crossword clue is the 7 letter word PANDORA

P
A
N
D
O
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A


Buddy explains!

The straight part
We know that "First Lady" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case first lady = pandora.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PANDORA mean?

PANDORA noun
  1. Any fish of the genus Pagellus.

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