Cryptic crossword clue
First of programs broadcast in twos 6

The most common and most likely answer to this crossword clue is the 6 letter word PAIRED

P
A
I
R
E
D

Buddy explains!

The straight part
We know that "in twos" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in twos = paired.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PAIRED mean?

PAIRED verb
  1. To group into one or more sets of two.
  2. To bring two (animals, notably dogs) together for mating.
  3. To engage (oneself) with another of opposite opinions not to vote on a particular question or class of questions.
  4. To suit; to fit, as a counterpart.
PAIRED verb
  1. To impair, to make worse.
  2. To become worse, to deteriorate.

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