Cryptic crossword clue
Fish in sea given drug, swimming with huge power 12

The most common and most likely answer to this crossword clue is the 12 letter word SUPERCHARGED

I've seen this crossword clue in The Guardian
S
U
P
E
R
C
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D

Buddy explains!

The straight part
We know that "with huge power" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with huge power = supercharged.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SUPERCHARGED mean?

SUPERCHARGED verb
  1. To increase the power of an internal combustion engine (either Otto or Diesel cycle) by compressing the inlet air with power extracted from the crankshaft.
  2. To make faster or more powerful.
  3. To overlay one charge upon another.
SUPERCHARGED adjective
  1. Equipped with a supercharger

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