Cryptic crossword clue
Five arriving at once with unknown illness 6

The most common and most likely answer to this crossword clue is the 6 letter word QUINSY

I've seen this crossword clue in Financial Times
Q
U
I
N
S
Y

Buddy explains!

The straight part
We know that "illness" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case illness = quinsy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does QUINSY mean?

QUINSY noun
  1. A peritonsillar abscess; a painful pus-filled inflammation or abscess of the tonsils and surrounding tissues, usually a complication of tonsillitis, caused by bacterial infection and often accompanied by fever.

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