Cryptic crossword clue
Flier the setter’s sent up in this vein? 6

The most common and most likely answer to this crossword clue is the 6 letter word MIDRIB

I've seen this crossword clue in The Daily Telegraph
M
I
D
R
I
B

Buddy explains!

The straight part
We know that "vein?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case vein? = midrib.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MIDRIB mean?

MIDRIB noun
  1. The strengthened vein down the middle of a flower petal or simple leaf or leaflet.
  2. The continuation of the petiole of a pinnately compound leaf around which the leaflets attach.

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