The most common and most likely answer to this crossword clue is the 4 letter word BLOB
I've seen this crossword clue in The Guardian
B
L
O
B
More clues leading to the result BLOB
- Hair arrangement hiding large lump
- Float up and down round large shapeless mass
- Bachelor to throw up small round mass
- Bowled by high ball, nothing scored?
- 24a’s baddie gets left in a sticky spot
- Round spot left in hair cut
- Drop bowled toss
- Haircut has large, indistinct shape
- Score of zero, bowled with ball in high, slow arc
Buddy explains!

The straight part
We know that "shapeless mass" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case shapeless mass = blob.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BLOB mean?
BLOB noun- A shapeless or amorphous mass; a vague shape or amount, especially of a liquid or semisolid substance; a clump, group or collection that lacks definite shape.
- In astronomy, a large cloud of gas. In particular, an extended Lyman-Alpha blob is a huge body of gas that may be the precursor to a galaxy.
- A bubble; a bleb.
- A small freshwater fish (Cottus bairdii); the miller's thumb.
- The partially inflated air bag used in the sport of blobbing.
- A score of zero.
- To drop in the form of a blob or blobs
- To drop a blob or blobs onto, cover with blobs.
- To fall in the form of a blob or blobs.
- To relax idly and mindlessly; to veg out.
- Acronym of binary large object. (a data type that allows storage of binary data often of indeterminate length).