Cryptic crossword clue
Flowering plant college planted in vain, shrivelled 5

The most common and most likely answer to this crossword clue is the 5 letter word VINCA

V
I
N
C
A

Buddy explains!

The straight part
We know that "Flowering plant" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case flowering plant = vinca.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VINCA mean?

VINCA noun
  1. Any of several evergreen shrubs, of the genus Vinca, including the periwinkle

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