Cryptic crossword clue
Fluff produced by cat lying around next to me 4,2

The most common and most likely answer to this crossword clue is the 4 plus 2 letter word MESS UP

M
E
S
S
U
P

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The straight part
We know that "Fluff" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fluff = mess up.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MESS UP mean?

MESS UP noun
  1. A mistake or fiasco; something that has gone wrong.

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