The most common and most likely answer to this crossword clue is the 6 letter word AVIATE
I've seen this crossword clue in The Guardian
A
V
I
A
T
E
More clues leading to the result AVIATE
- Fly as ace through start of thunderstorm and escape finally
- Go by plane steered round Latvia heading off east
- Fly worried about going through
- Fly polished off by means of pins
- Fly from Syria via Tehran
- Fly first by way of the original Terminal One
- A struggle to pack a ton and fly
- Last of malaria through extremities of tsetse fly
- Had a bite outside by fly
- A victory — one swallowed fly
Buddy explains!

The straight part
We know that "Fly" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fly = aviate.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does AVIATE mean?
AVIATE verb- To operate an aircraft.