The most common and most likely answer to this crossword clue is the 10 letter word FRUSTRATES
I've seen this crossword clue in The Daily Telegraph
F
R
U
S
T
R
A
T
E
S
More clues leading to the result FRUSTRATES
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does FRUSTRATES mean?
FRUSTRATES verb- To disappoint or defeat; to vex by depriving of something expected or desired.
- To hinder or thwart.
- To cause stress or annoyance.