The most common and most likely answer to this crossword clue is the 10 letter word PRAGMATISM
I've seen this crossword clue in The Daily Telegraph
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does PRAGMATISM mean?
PRAGMATISM noun- The pursuit of practicality over aesthetic qualities; a concentration on facts rather than emotions or ideals.
- The theory that political problems should be met with practical solutions rather than ideological ones.
- The idea that beliefs are identified with the actions of a believer, and the truth of beliefs with success of those actions in securing a believer's goals; the doctrine that ideas must be looked at in terms of their practical effects and consequences.
- The habit of interfering in other people's affairs; meddlesomeness.