Cryptic crossword clue
For each upset select man changing substitutes 12

The most common and most likely answer to this crossword clue is the 12 letter word REPLACEMENTS

I've seen this crossword clue in The Daily Telegraph
R
E
P
L
A
C
E
M
E
N
T
S

Buddy explains!

The straight part
We know that "substitutes" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case substitutes = replacements.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REPLACEMENTS mean?

REPLACEMENTS noun
  1. A person or thing that takes the place of another; a substitute.
  2. The act of replacing something.
  3. The removal of an edge of crystal, by one plane or more.

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