The most common and most likely answer to this crossword clue is the 6 letter word FEMALE
I've seen this crossword clue in The Guardian
F
E
M
A
L
E
More clues leading to the result FEMALE
- Free meal regularly offered by the French woman?
- Parent left in charge of one similar?
- Iron Man’s 13, reportedly one that’s unlike him
- One that makes master feel inadequate?
- For example, initially he or she
- Feel awkward about the old lady suggesting sex?
- Mother left in charge, unlike father
- English pound up under Iron Lady
- Iron man? More deadly, Kipling said
- Ladylike fellow's weak, upset with sweetheart
Buddy explains!

The straight part
We know that "she" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case she = female.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does FEMALE mean?
FEMALE noun- One of the female (feminine) sex or gender.
- Belonging to the sex which typically produces eggs (ova), or to the gender which is typically associated with it.
- Characteristic of this sex/gender. (Compare feminine, womanly.)
- Tending to lead to or regulate the development of sexual characteristics typical of this sex.
- (grammar, less common than 'feminine') Feminine; of the feminine grammatical gender.
- Having an internal socket, as in a connector or pipe fitting.