Cryptic crossword clue
For example, initially he or she 6

The most common and most likely answer to this crossword clue is the 6 letter word FEMALE

I've seen this crossword clue in The Guardian
F
E
M
A
L
E


Buddy explains!

The straight part
We know that "she" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case she = female.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FEMALE mean?

FEMALE noun
  1. One of the female (feminine) sex or gender.
FEMALE adjective
  1. Belonging to the sex which typically produces eggs (ova), or to the gender which is typically associated with it.
  2. Characteristic of this sex/gender. (Compare feminine, womanly.)
  3. Tending to lead to or regulate the development of sexual characteristics typical of this sex.
  4. (grammar, less common than 'feminine') Feminine; of the feminine grammatical gender.
  5. Having an internal socket, as in a connector or pipe fitting.

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