Cryptic crossword clue
For stand-ups it’s run-of-the-mill to be beset by heartless catcalls 6

The most common and most likely answer to this crossword clue is the 6 letter word JOKERS

J
O
K
E
R
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does JOKERS mean?

JOKERS noun
  1. A person who makes jokes.
  2. A funny person.
  3. A jester.
  4. A playing card that features a picture of a joker (that is, a jester) and that may be used as a wild card in some card games.
  5. An unspecified, vaguely disreputable person.
  6. A man.
  7. A clause in a contract that undermines its apparent provisions.

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