The most common and most likely answer to this crossword clue is the 11 letter word SEPARATISTS
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Buddy explains!
The straight part
We know that "For whom south, set apart, is potentially enough?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case for whom south, set apart, is potentially enough? = separatists.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SEPARATISTS mean?
SEPARATISTS noun- Someone who advocates separation from the established Church; a member of any of various sects or schismatics.
- A person who advocates or seeks the splitting of one country or territory into two politically independent countries or territories.