The most common and most likely answer to this crossword clue is the 6 letter word FLYING
I've seen this crossword clue in Financial Times
F
L
Y
I
N
G
More clues leading to the result FLYING
- Initially fast, then flat out?
- Travelling overseas? There’s romance about the unknown
- Insect – one no good on the wing
- Very brief dance around yard
- Brief avian activity
- Force probably on the ground or up in the air
- Fellow making things up going on air
- Fast food’s leader producing Whopper?
- Very quick affair involving you at first
- Rushed fellow telling story
Buddy explains!

The straight part
We know that "up in the air" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case up in the air = flying.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does FLYING mean?
FLYING verb- To hit a fly ball; to hit a fly ball that is caught for an out. Compare ground (verb) and line (verb).
- To travel through the air, another gas or a vacuum, without being in contact with a grounded surface.
- To flee, to escape (from).
- To cause to fly (travel or float in the air): to transport via air or the like.
- (of a proposal, project or idea) To be accepted, come about or work out.
- To travel very fast, hasten.
- To move suddenly, or with violence; to do an act suddenly or swiftly.
- To display (a flag) on a flagpole.
- To hunt with a hawk.
- That flies or can fly.
- Brief or hurried.
- (of a sail) Not secured by yards.
- An act of flight.
- The action or process of sustained motion through the air.