The most common and most likely answer to this crossword clue is the 6 letter word RECTUM
R
E
C
T
U
M
More clues leading to the result RECTUM
Buddy explains!
The straight part
We know that "many a politician talks through it?!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case many a politician talks through it?! = rectum.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does RECTUM mean?
RECTUM noun- The terminal part of the large intestine through which feces pass after exiting the colon.