Cryptic crossword clue
Former hospital north of state capital tackling oxygen fatigue 10

The most common and most likely answer to this crossword clue is the 10 letter word EXHAUSTION

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Buddy explains!

The straight part
We know that "fatigue" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fatigue = exhaustion.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EXHAUSTION mean?

EXHAUSTION noun
  1. The point of complete depletion, of the state of being used up.
  2. Supreme tiredness; having exhausted energy.
  3. The removal (by percolation etc) of an active medicinal constituent from plant material.
  4. The removal of all air from a vessel (the creation of a vacuum).
  5. An exhaustive procedure

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