Cryptic crossword clue
Former US president’s wife‘s spotted small creatures 9

The most common and most likely answer to this crossword clue is the 9 letter word LADYBIRDS

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does LADYBIRDS mean?

LADYBIRDS noun
  1. Any of the Coccinellidae family of beetles, typically having a round shape and red or yellow spotted elytra.

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