The most common and most likely answer to this crossword clue is the 7 plus 5 plus 4 letter word ABANDON ONE’S POST
I've seen this crossword clue in The Guardian
A
B
A
N
D
O
N
O
N
E
â
€
™
S
P
O
S
T
More clues leading to the result ABANDON ONE’S POST
Buddy explains!

The straight part
We know that "Forsake your responsibilities" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case forsake your responsibilities = abandon one’s post.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.