The most common and most likely answer to this crossword clue is the 10 letter word ARCHITRAVE
I've seen this crossword clue in The Sunday Telegraph
A
R
C
H
I
T
R
A
V
E
More clues leading to the result ARCHITRAVE
Buddy explains!

The straight part
We know that "Frame" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case frame = architrave.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ARCHITRAVE mean?
ARCHITRAVE noun- The lowest part of an entablature; rests on the capitals of the columns.
- The moldings (or other elements) framing a door, window or other rectangular opening.