The most common and most likely answer to this crossword clue is the 7 letter word MUTANTS
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More clues leading to the result MUTANTS
Buddy explains!
The straight part
We know that "Freaks of nature" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case freaks of nature = mutants.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MUTANTS mean?
MUTANTS noun- Something which has mutated, which has one or more new characteristics from a mutation.
- Someone or something that seems strange, abnormal, or bizarre.
- An object in a program that serves as a lock, used to negotiate mutual exclusion among threads.