The most common and most likely answer to this crossword clue is the 10 letter word CRYOGENICS
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does CRYOGENICS mean?
CRYOGENICS noun- The science and technology of the production of very low temperatures.
- The scientific study of low-temperature phenomena.