Cryptic crossword clue
Fresh air given to perk up 10

The most common and most likely answer to this crossword clue is the 10 letter word INVIGORATE

I've seen this crossword clue in The Daily Telegraph
I
N
V
I
G
O
R
A
T
E

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INVIGORATE mean?

INVIGORATE verb
  1. To impart vigor, strength, or vitality to.
  2. To heighten or intensify.
  3. To give life or energy to.
  4. To make lively.

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