Cryptic crossword clue
Friends heading further south to find what once divided Gaul and Rome

The most common and most likely answer to this crossword clue is the 4 letter word ALPS

I've seen this crossword clue in Independent
A
L
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Buddy explains!

The straight part
We know that "what once divided Gaul and Rome" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what once divided gaul and rome = alps.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ALPS mean?

ALPS noun
  1. A very high mountain. Specifically, one of the Alps, the highest chain of mountains in Europe.

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