The most common and most likely answer to this crossword clue is the 6 letter word AMIGOS
A
M
I
G
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S
More clues leading to the result AMIGOS
Buddy explains!

The straight part
We know that "Friends" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case friends = amigos.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does AMIGOS mean?
AMIGOS noun- Friend
- (chiefly California) Mexican
- A native of the Philippines who was friendly toward the Spanish.