Cryptic crossword clue
From study of its origins, designed Yeti logo

The most common and most likely answer to this crossword clue is the 8 letter word ETIOLOGY

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does ETIOLOGY mean?

ETIOLOGY noun
  1. The establishment of a cause, origin, or reason for something.
  2. The study of causes or causation.
  3. The study or investigation of the causes of disease; a scientific explanation for the origin of a disease.

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