Cryptic crossword clue
Fruit mostly heading off endemic skin disease 5

The most common and most likely answer to this crossword clue is the 5 letter word MANGE

I've seen this crossword clue in Financial Times
M
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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does MANGE mean?

MANGE noun
  1. A skin disease of mammals caused by parasitic mites (Sarcoptes spp., Demodecidae spp.).

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