Cryptic crossword clue
Frustrate a sad don desperately wanting liquor 6,3,4

The most common and most likely answer to this crossword clue is the 6 plus 3 plus 4 letter word SCOTCH AND SODA

S
C
O
T
C
H
A
N
D
S
O
D
A

Buddy explains!

The straight part
We know that "liquor" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case liquor = scotch and soda.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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