Cryptic crossword clue
Frustrating skin defect in article 9

The most common and most likely answer to this crossword clue is the 9 letter word THWARTING

I've seen this crossword clue in The Guardian
T
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Buddy explains!

The straight part
We know that "Frustrating" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case frustrating = thwarting.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does THWARTING mean?

THWARTING verb
  1. To cause to fail; to frustrate, to prevent.
  2. To place (something) across (another thing); to position crosswise.
  3. To hinder or obstruct by placing (something) in the way of; to block, to impede, to oppose.
  4. To move (something) across or counter to; to cross.
THWARTING noun
  1. An instance of blocking or obstructing.

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