The most common and most likely answer to this crossword clue is the 4 plus 3 plus 6 letter word TURN THE TABLES
I've seen this crossword clue in The Daily Telegraph
T
U
R
N
T
H
E
T
A
B
L
E
S
More clues leading to the result TURN THE TABLES
- Hunters battle, frantically, to go from disadvantage to advantage?
- Hunter battles to alter and completely reverse positions
- Change what one plays in casino and get ahead after being behind?
- But nettlerash can erupt and gain the ascendancy
- Troubled hunter battles to get the upper hand
- Article among DJs’ equipment to overcome disadvantage
- But nettle-rash can erupt and gain the ascendancy
- Gain upper hand, seeing article covered by Spinners
- But slattern he summoned could well achieve complete reversal
- What spiritualists at séances might do to bring about a complete reversal?
Buddy explains!

The straight part
We know that "Gain upper hand" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case gain upper hand = turn the tables.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.