Cryptic crossword clue
Gallivants around playing organs, which will generate issue 6

The most common and most likely answer to this crossword clue is the 6 letter word GONADS

I've seen this crossword clue in The Guardian
G
O
N
A
D
S

Buddy explains!

The straight part
We know that "organs, which will generate issue" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case organs, which will generate issue = gonads.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GONADS mean?

GONADS noun
  1. A sex organ that produces gametes; specifically, a testicle or ovary.
  2. (chiefly in the plural) The testicles.

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