The most common and most likely answer to this crossword clue is the 4 letter word LUDO
I've seen this crossword clue in The Guardian
L
U
D
O
More clues leading to the result LUDO
- Turn over mostly pedestrian game
- Terribly loud board contest
- Ivy follows line that’s contested on the board
- Game I play in Rome once
- Let us discuss our starters
- Only 40% lucky at party game
- Competitive game, universal in Liberal party
- Board game clue uncovered cheat
- Number taking turn at party game
- United in funny old game
Buddy explains!

The straight part
We know that "Game/I play in Rome once" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case game/i play in rome once = ludo.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LUDO mean?
LUDO noun- A children's board game in which tokens are moved round a board.