Cryptic crossword clue
Game old ladies knocked back bottle 6

The most common and most likely answer to this crossword clue is the 6 letter word VALOUR

I've seen this crossword clue in Financial Times
V
A
L
O
U
R

Buddy explains!

The straight part
We know that "bottle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bottle = valour.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VALOUR mean?

VALOUR noun
  1. Value; worth.
  2. Strength of mind in regard to danger; the quality which enables a person to encounter danger with firmness
  3. A brave man; a man of valour.

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