Cryptic crossword clue
Game vetting managed by major organisation 5-2-2

The most common and most likely answer to this crossword clue is the 11 letter word VINGT-ET-UN

I've seen this crossword clue in The Guardian
V
I
N
G
T
-
E
T
-
U
N

Buddy explains!

The straight part
We know that "Game" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case game = vingt-et-un.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VINGT-ET-UN mean?

VINGT-ET-UN noun
  1. The card game pontoon.

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