Cryptic crossword clue
Gave in a hundred pounds to get hold of key drug 10

The most common and most likely answer to this crossword clue is the 10 letter word ACQUIESCED

I've seen this crossword clue in The Times
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The straight part
We know that "Gave in" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case gave in = acquiesced.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACQUIESCED mean?

ACQUIESCED verb
  1. (with in (or sometimes with, to)) To rest satisfied, or apparently satisfied, or to rest without opposition and discontent (usually implying previous opposition or discontent); to accept or consent by silence or by omitting to object.
  2. To concur upon conviction; as, to acquiesce in an opinion; to assent to; usually, to concur, not heartily but so far as to forbear opposition.

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