The most common and most likely answer to this crossword clue is the 2 plus 3 plus 5 letter word BY AND LARGE
B
Y
A
N
D
L
A
R
G
E
More clues leading to the result BY AND LARGE
- Year in company great, on the whole
- German dons drunk brandy with ale mostly
- Anger badly dealt with on the whole
- Generally unknown land newly rounded by boat
- Through with sweeping, on the whole
- Anger badly managed, on the whole
- Dylan at sea aboard pleasure-boat on the whole
- Speaking generally, XL?
- Year in orchestra — great, on the whole
- Year employed by group — great, on the whole
Buddy explains!

The straight part
We know that "Generally" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case generally = by and large.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.