Cryptic crossword clue
Get one’s own back with a volume on gene mutation

The most common and most likely answer to this crossword clue is the 6 letter word AVENGE

I've seen this crossword clue in The Guardian
A
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Buddy explains!

The straight part
We know that "Get one’s own back" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case get one’s own back = avenge.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AVENGE mean?

AVENGE noun
  1. An act of vengeance; a revenge.
AVENGE verb
  1. To take vengeance (for); to exact satisfaction for by punishing the injuring party; to vindicate by inflicting pain or evil on a wrongdoer.
  2. To take vengeance.
  3. To treat revengefully; to wreak vengeance on.

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