Cryptic crossword clue
Getting to the end of this exhausts one’s patience 6

The most common and most likely answer to this crossword clue is the 6 letter word TETHER

I've seen this crossword clue in The Guardian
T
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Buddy explains!

The straight part
We know that "Getting to the end of this exhausts one’s patience" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case getting to the end of this exhausts one’s patience = tether.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TETHER mean?

TETHER noun
  1. A rope, cable etc. that holds something in place whilst allowing some movement
  2. A strong rope or line that connects a sailor's safety harness to the boat's jackstay
  3. (by extension) the limit of one's abilities, resources etc.
  4. The cardinal number three in an old counting system used in Teesdale and Swaledale. (Variant of tethera)
TETHER verb
  1. To restrict something with a tether.
  2. To connect a cellular smartphone to another personal computer in order to give it access to a hotspot.

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