Cryptic crossword clue
Giant killers involved in major case 5

The most common and most likely answer to this crossword clue is the 5 letter word ORCAS

O
R
C
A
S


Buddy explains!

The straight part
We know that "Giant killers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case giant killers = orcas.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ORCAS mean?

ORCAS noun
  1. A sea mammal (Orcinus orca) related to dolphins and porpoises, commonly called the killer whale.

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