The most common and most likely answer to this crossword clue is the 4 letter word TINA
T
I
N
A
More clues leading to the result TINA
- Girl adopted by Maggie Thatcher initially
- Girl, a 7, can answer
- Girl embodying Margaret Thatcher’s single-minded approach
- She’ll be a fool if she comes back
- Soldier describes one returning for 11a
- Mrs T‘s comment, in short: ‘Some of humanity is for turning!’
- Girl, one with sex-appeal, upset
- Mrs T. can, at first
- There is no alternative, initially, to her
Buddy explains!

The straight part
We know that "Girl/Margaret Thatcher’s single-minded approach" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case girl/margaret thatcher’s single-minded approach = tina.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.