Cryptic crossword clue
Girl endlessly upset with spike embedded in part of body 6

The most common and most likely answer to this crossword clue is the 6 letter word SPINAL

S
P
I
N
A
L


Buddy explains!

The straight part
We know that "in part of body" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in part of body = spinal.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SPINAL mean?

SPINAL noun
  1. A spinal anesthesia.
SPINAL adjective
  1. Of or relating to the spine.
  2. (of a frog, or other experimental animal) Having a pithed brain, but an intact spinal cord.

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