The most common and most likely answer to this crossword clue is the 6 letter word LASSIE
I've seen this crossword clue in The Times
L
A
S
S
I
E
More clues leading to the result LASSIE
- Story about equine female from Scotland
- Name of dog that is following girl
- Story about animal
- Girl’s deceit taking Charlie in
- Owner of bark in films sails out east
- Girl's story about donkey
- Film star, fool taken in by fraud
- Haile Selassie’s dog?
- Reportedly, Indian drink for 16
- Young girl‘s story about a ship
Buddy explains!

The straight part
We know that "Girl" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case girl = lassie.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LASSIE mean?
LASSIE noun- A young girl, a lass, especially one seen as a sweetheart.