Cryptic crossword clue
Give fresh instructions on radio presentation 11

The most common and most likely answer to this crossword clue is the 11 letter word REPROGRAMME

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Buddy explains!

The straight part
We know that "Give fresh instructions" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case give fresh instructions = reprogramme.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REPROGRAMME mean?

REPROGRAMME verb
  1. To program anew or differently.
  2. (by extension) To make a fundamental change to the behaviour or habits of.
  3. To shift funds appropriated for one government program to a different government program.

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