The most common and most likely answer to this crossword clue is the 6 letter word DONATE
I've seen this crossword clue in The Times
D
O
N
A
T
E
More clues leading to the result DONATE
- Give Spanish noblewoman note
- Gift is acceptable, wrapped by partner
- Academic took in offer
- Give university lecturer freshly made tea
- Mafia boss had to chip in
- Be charitable when prospective partner holds forth
- Grant’s about to cut fruit
- Member of university staff had to be present
- Spanish gentleman devoured present
- Give fruit on entering
Buddy explains!

The straight part
We know that "Give" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case give = donate.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DONATE mean?
DONATE verb- To make a donation; to give away something of value to support or contribute towards a cause or for the benefit of another.