Cryptic crossword clue
Give up, having been broken by large loss of energy? 8

The most common and most likely answer to this crossword clue is the 8 letter word BLACKOUT

B
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Buddy explains!

The straight part
We know that "loss of energy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loss of energy = blackout.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BLACKOUT mean?

BLACKOUT noun
  1. A temporary loss of consciousness.
  2. A temporary loss of memory.
  3. An instance of censorship, especially a temporary one.
  4. A large-scale power failure, and resulting loss of electricity to consumers.
  5. The mandatory blocking of all light emanating from buildings as imposed during World War II.

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