Cryptic crossword clue
Given charges, one on one, that’s me losing my first! 7

The most common and most likely answer to this crossword clue is the 7 letter word IONIZED

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Buddy explains!

The straight part
We know that "Given charges" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case given charges = ionized.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IONIZED mean?

IONIZED verb
  1. To dissociate atoms or molecules into electrically charged species; to be thus dissociated.

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